Melanocortin receptor agonist and metabolite of Melanotan-2. Subject of clinical research examining central MC3R/MC4R-mediated autonomic nervous system signaling pathways.
PT-141 (bremelanotide) is a melanocortin-receptor research compound that straddles two very different buyer markets — institutional research and private sourcing. For both, the china peptide sourcing calculus is the same: identity, purity, and lyophilization quality. We supply PT-141 as a finished vial from an established Chinese manufacturer, with the specification stated up front rather than discovered after delivery.
Buy PT-141 (Bremelanotide) | Research Grade | Peptides of China PT-141 (Bremelanotide) Buy PT-141 (Bremelanotide) — Research Grade Peptide PT-141 (Bremelanotide) is a sexual health research compound currently in stock directly from a verified Chinese manufacturer. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control. Sourcing is direct — no intermediaries. Public catalog minimum is $300 in goods per supplier. Eligible new customers may use one first-order trial without a monetary minimum; 5% off goods applies from $3,500 per supplier, excluding shipping. International shipping available.
Compound Profile
PT-141, also known by its INN bremelanotide, is a cyclic heptapeptide melanocortin receptor agonist. It is a metabolite-analogue of Melanotan-2, produced by removal of the C-terminal amide and cyclisation via a lactam bridge, but distinguished by the absence of melanogenic activity at therapeutic doses — a significant pharmacological distinction from MT-2. PT-141 preferentially activates MC3R (melanocortin-3 receptor) and MC4R (melanocortin-4 receptor) over the melanogenesis-linked MC1R, localising its primary preclinical research interest to CNS-mediated arousal pathways and inflammatory modulation. The compound has completed a full clinical development programme for hypoactive sexual desire disorder (HSDD) in premenopausal women, making it one of the few research peptides with a complete translational research record spanning preclinical to Phase III. Preclinical research on PT-141 spans MC4R-mediated sexual arousal circuits, inflammatory signalling via MC3R in macrophage and endothelial models, and nociception. The MC4R activation pathway in the hypothalamus and limbic system forms the mechanistic basis for PT-141’s CNS-mediated effects, distinct from vasodilatory mechanisms studied with earlier arousal research compounds. Research into MC3R activation has separately characterised anti-inflammatory cytokine modulation, TNF-α suppression, and endotoxin response models — areas studied independently of the arousal research line. Peptides of China supplies research-grade PT-141 (bremelanotide) as lyophilized powder at ≥98% purity, confirmed by HPLC and mass spectrometry. Batch Certificates of Analysis are available. All product is intended for laboratory research use only and is not for human administration.
Profile
Available Variants
| Name | Strength | Pack Size | Purity | Availability |
|---|---|---|---|---|
| PT-141 (Bremelanotide) | 10 mg | 10 vials | ≥98% | In Stock |
| PT-141 (Bremelanotide) | 10 mg | 10 vials | — | In Stock |
Specification Highlights
Quality & Testing
Testing method: HPLC / LC-MS . Products are supplied against the specification shown on the applicable product page. The standard catalog purity specification is ≥98% unless otherwise stated. Product-specific specifications and quality-control information may vary by compound and batch. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control, using methods such as HPLC and LC-MS. These results are kept in the manufacturer’s internal quality-control records and are not issued as a separate certificate or document.
Research Areas
Melanocortin Receptor Pharmacology PT-141’s receptor selectivity profile (MC3R > MC4R >> MC1R) makes it a valuable tool for dissecting melanocortin receptor subtype contributions in complex phenotypes. Binding assays and functional cAMP accumulation experiments in MC-receptor transfected cell lines are used to quantify affinity and potency. The compound’s cyclic structure confers improved metabolic stability relative to linear melanocortin analogues, extending its utility in ex vivo and short-duration in vivo assays. CNS Arousal & Hypothalamic Signalling MC4R is expressed in paraventricular hypothalamic neurons and limbic circuits involved in motivational and reward behaviour. Preclinical rodent studies demonstrate that intracranial or peripheral PT-141 administration increases sexual behaviour in both male (mount frequency, intromission) and female (lordosis quotient) models in a dose-dependent, MC4R-dependent manner. These studies utilise MC4R knockout models to confirm receptor specificity and distinguish from MT-2’s broader melanocortin effects. Human clinical data from the bremelanotide development program provide a rare translational dataset for cross-species comparison. Inflammatory & Immune Modulation via MC3R The MC3R, expressed in macrophages, dendritic cells, and endothelial cells, mediates anti-inflammatory signalling in response to melanocortin agonism. PT-141 and related MC3R agonists suppress LPS-induced TNF-α and IL-6 production in macrophage cell line models (RAW264.7, THP-1). In vivo carrageenan-induced paw oedema and endotoxaemia rodent models demonstrate PT-141’s anti-inflammatory activity. This research line is independent of the arousal pathway and is studied in the context of melanocortin system modulation of innate immunity. Haemodynamic & Cardiovascular Effects Clinical pharmacokinetic data from PT-141 trials documented transient blood pressure elevation (peak ~4 mmHg systolic), attributed to peripheral MC1R/MC3R-mediated vasoconstriction rather than the vasodilatory mechanisms of phosphodiesterase inhibitors. Preclinical rodent and primate haemodynamic studies are used to characterise dose-pressure response relationships and identify the receptor subtypes mediating cardiovascular effects — data relevant to structuring safe research protocols and interpreting cardiovascular safety endpoints in melanocortin research. ## Sourcing PT-141 (Bremelanotide) From China
PT-141 (Bremelanotide) is available through our platform as a china peptide sourced directly from an established Chinese manufacturer. Three points define how we handle it:
- Factory-direct, not trader-sourced. We confirm availability and specification with the manufacturer before the order is confirmed. There is no intermediary resale of unknown-origin vials in this catalog.
- Specification before shipment. The purity and concentration specification shown on this page is the manufacturer’s batch specification. Product-specific quality-control information travels with the order.
- Research-use discipline. Like every listing in our catalog, PT-141 (Bremelanotide) is supplied for laboratory research use only, under strict research-use terms.
For buyers comparing chinese peptides suppliers, the practical test is whether the seller can name the manufacturer and show the batch documentation. We work the other way around: the manufacturer and the documentation are the offer. Browse the full catalog or see how sourcing works.