Acetyl octapeptide-3 — synthetic analog of the N-terminal fragment of SNAP-25. Studied in cosmetic research for SNARE protein modulation and neuromuscular junction signaling at the dermal level.
SNAP-8 is a research compound available through our china peptide catalog as a finished, lyophilized vial from an established Chinese manufacturer. It belongs to the Synthetic octapeptide / SNARE complex competitive analogue
Research Areas
SNARE complex pharmacology, catecholamine exocytosis, neuro-muscular junction research, skin biology
Available Variants
| Name | Strength | Pack Size | Purity | Availability |
|---|---|---|---|---|
| SNAP-8 | 10 mg | 10 vials | ≥98% | In Stock |
Specification Highlights
Quality & Testing
Testing method: HPLC / LC-MS . Products are supplied against the specification shown on the applicable product page. The standard catalog purity specification is ≥98% unless otherwise stated. Product-specific specifications and quality-control information may vary by compound and batch. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control, using methods such as HPLC and LC-MS. These results are kept in the manufacturer’s internal quality-control records and are not issued as a separate certificate or document.
Research Areas
SNARE Complex Inhibition Research SNAP-8 provides a research tool for studying SNARE complex-dependent exocytosis without the irreversible proteolytic mechanism of botulinum toxins. Research has examined SNAP-8’s ability to compete with endogenous SNAP-25 in SNARE complex assembly assays, measuring its inhibitory constant (IC₅₀) against SNARE zippering in reconstituted membrane fusion systems. This competitive, reversible inhibition makes SNAP-8 useful for dose-response studies where SNARE complex formation must be titrated rather than abolished. Catecholamine Exocytosis in Skin Models Skin neuro-muscular junctions release noradrenaline via SNARE-dependent exocytosis to stimulate expression muscle fibers. Research using SNAP-8 in skin culture models and ex vivo tissue preparations has examined whether SNARE complex inhibition reduces catecholamine release, muscle contraction markers, and downstream extracellular matrix changes at the neuronal junction. These studies provide mechanistic context for the compound’s proposed dermatological applications. SNAP-25 Peptide Structure-Activity Research The minimal SNAP-25 sequence required for SNARE complex binding and inhibition has been studied using truncated and modified SNAP-25 peptide fragments. SNAP-8 represents a well-characterized octapeptide probe in this structure-activity space. Comparative studies with shorter or longer SNAP-25 fragments help define the binding pharmacophore required for competitive SNARE inhibition — contributing to peptide design research in the SNARE biology field. ## Sourcing SNAP-8 From China
SNAP-8 is available through our platform as a china peptide sourced directly from an established Chinese manufacturer. Three points define how we handle it:
- Factory-direct, not trader-sourced. We confirm availability and specification with the manufacturer before the order is confirmed. There is no intermediary resale of unknown-origin vials in this catalog.
- Specification before shipment. The purity and concentration specification shown on this page is the manufacturer’s batch specification. Product-specific quality-control information travels with the order.
- Research-use discipline. Like every listing in our catalog, SNAP-8 is supplied for laboratory research use only, under strict research-use terms.
For buyers comparing chinese peptides suppliers, the practical test is whether the seller can name the manufacturer and show the batch documentation. We work the other way around: the manufacturer and the documentation are the offer. Browse the full catalog or see how sourcing works.
Available Variants
| Name | Strength | Pack Size | Purity | Availability |
|---|---|---|---|---|
| SNAP-8 | 10 mg | 10 vials | ≥98% | In Stock |
Specification Highlights
Quality & Testing
Testing method: HPLC / LC-MS . Products are supplied against the specification shown on the applicable product page. The standard catalog purity specification is ≥98% unless otherwise stated. Product-specific specifications and quality-control information may vary by compound and batch. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control, using methods such as HPLC and LC-MS. These results are kept in the manufacturer’s internal quality-control records and are not issued as a separate certificate or document.
Research Areas
SNARE Complex Inhibition Research SNAP-8 provides a research tool for studying SNARE complex-dependent exocytosis without the irreversible proteolytic mechanism of botulinum toxins. Research has examined SNAP-8’s ability to compete with endogenous SNAP-25 in SNARE complex assembly assays, measuring its inhibitory constant (IC₅₀) against SNARE zippering in reconstituted membrane fusion systems. This competitive, reversible inhibition makes SNAP-8 useful for dose-response studies where SNARE complex formation must be titrated rather than abolished. Catecholamine Exocytosis in Skin Models Skin neuro-muscular junctions release noradrenaline via SNARE-dependent exocytosis to stimulate expression muscle fibers. Research using SNAP-8 in skin culture models and ex vivo tissue preparations has examined whether SNARE complex inhibition reduces catecholamine release, muscle contraction markers, and downstream extracellular matrix changes at the neuronal junction. These studies provide mechanistic context for the compound’s proposed dermatological applications. SNAP-25 Peptide Structure-Activity Research The minimal SNAP-25 sequence required for SNARE complex binding and inhibition has been studied using truncated and modified SNAP-25 peptide fragments. SNAP-8 represents a well-characterized octapeptide probe in this structure-activity space. Comparative studies with shorter or longer SNAP-25 fragments help define the binding pharmacophore required for competitive SNARE inhibition — contributing to peptide design research in the SNARE biology field.
Compound Profile
SNAP-8 (Acetyl Octapeptide-3) is a synthetic octapeptide functionally related to the N-terminal peptide region of SNAP-25 (synaptosomal-associated protein 25), a key component of the SNARE complex responsible for neurotransmitter vesicle fusion at synaptic terminals. The SNARE complex also mediates catecholamine release from cutaneous neuronal junctions, which drives contraction of expression muscles. By providing a competitive analogue of the SNAP-25 binding site, SNAP-8 is studied as a potential inhibitor of SNARE complex assembly at the neuro-muscular junction — a mechanism proposed to reduce muscle contraction amplitude at the site of application. Research into SNAP-8 examines its ability to inhibit catecholamine exocytosis from neuronal terminals in skin — specifically, the noradrenaline release that triggers receptor-mediated muscle fiber contraction. In contrast to botulinum toxin, which cleaves SNAP-25 irreversibly, SNAP-8 provides a reversible competitive peptide that can be used to study SNARE-mediated exocytosis in dermal research models without permanent enzymatic destruction of the SNARE machinery. Research applications include studies of neuro-muscular junction pharmacology in skin, SNARE complex assembly kinetics, and catecholamine exocytosis modulation in cutaneous tissues. Peptides of China supplies SNAP-8 as a lyophilized powder at 99%+ purity, verified by HPLC and Mass Spectrometry. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control. All products are for laboratory research use only and are not for human consumption.
Profile
Research Areas
SNARE complex pharmacology, catecholamine exocytosis, neuro-muscular junction research, skin biology
Available Variants
| Name | Strength | Pack Size | Purity | Availability |
|---|---|---|---|---|
| SNAP-8 | 10 mg | 10 vials | ≥98% | In Stock |
Specification Highlights
Quality & Testing
Testing method: HPLC / LC-MS . Products are supplied against the specification shown on the applicable product page. The standard catalog purity specification is ≥98% unless otherwise stated. Product-specific specifications and quality-control information may vary by compound and batch. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control, using methods such as HPLC and LC-MS. These results are kept in the manufacturer’s internal quality-control records and are not issued as a separate certificate or document.
Research Areas
SNARE Complex Inhibition Research SNAP-8 provides a research tool for studying SNARE complex-dependent exocytosis without the irreversible proteolytic mechanism of botulinum toxins. Research has examined SNAP-8’s ability to compete with endogenous SNAP-25 in SNARE complex assembly assays, measuring its inhibitory constant (IC₅₀) against SNARE zippering in reconstituted membrane fusion systems. This competitive, reversible inhibition makes SNAP-8 useful for dose-response studies where SNARE complex formation must be titrated rather than abolished. Catecholamine Exocytosis in Skin Models Skin neuro-muscular junctions release noradrenaline via SNARE-dependent exocytosis to stimulate expression muscle fibers. Research using SNAP-8 in skin culture models and ex vivo tissue preparations has examined whether SNARE complex inhibition reduces catecholamine release, muscle contraction markers, and downstream extracellular matrix changes at the neuronal junction. These studies provide mechanistic context for the compound’s proposed dermatological applications. SNAP-25 Peptide Structure-Activity Research The minimal SNAP-25 sequence required for SNARE complex binding and inhibition has been studied using truncated and modified SNAP-25 peptide fragments. SNAP-8 represents a well-characterized octapeptide probe in this structure-activity space. Comparative studies with shorter or longer SNAP-25 fragments help define the binding pharmacophore required for competitive SNARE inhibition — contributing to peptide design research in the SNARE biology field.