Epithalon (Epitalon) research peptide sourced directly from China. Purity and concentration verified per batch. Popular in longevity research.
Epithalon (Epitalon) has anchored longevity and telomere research in the china peptide space for over a decade. The compound is short, cheap to synthesize, and therefore heavily commoditized — which makes sourcing quality the entire ballgame for chinese peptides buyers. Our Epithalon is supplied as finished lyophilized product from an established Chinese manufacturer with documented purity per batch.
Buy Epithalon Peptide | Research Grade, Purity Tested | Peptides of China Epithalon Buy Epithalon (Epitalon) — Longevity Peptide, Research Grade Epithalon is a anti-aging & longevity research compound currently in stock directly from a verified Chinese manufacturer. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control. Sourcing is direct — no intermediaries. Public catalog minimum is $300 in goods per supplier. Eligible new customers may use one first-order trial without a monetary minimum; 5% off goods applies from $3,500 per supplier, excluding shipping. International shipping available.
Compound Profile
Epithalon (also spelled Epitalon or Epithalone) is a synthetic tetrapeptide — Ala-Glu-Asp-Gly — derived from epithalamin, a polypeptide fraction isolated from the bovine pineal gland by Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology. The four-amino acid sequence represents the bioactive core of the parent peptide. Research interest in epithalon centres on its reported ability to stimulate telomerase (hTERT) expression in somatic cells, a mechanism that has driven its investigation in cellular ageing models. The compound was developed within the Soviet and Russian peptide bioregulator research tradition, and the majority of foundational studies originate from Khavinson’s laboratory, with subsequent work by international groups focused on mechanistic validation. The primary proposed mechanism of epithalon involves stimulation of telomerase reverse transcriptase (hTERT) activity and elongation of telomeres in cultured human cells. In vitro studies in primary human fibroblast and retinal pigment epithelium (RPE) cell lines report increased telomere length and extended replicative lifespan following epithalon treatment. Separately, research has examined epithalon’s effects on pineal melatonin synthesis and circadian rhythm regulation in aged rodent models, consistent with its origin as a pineal-derived peptide bioregulator. Anti-oxidant activity via catalase and superoxide dismutase upregulation has also been characterised in hepatocyte and lymphocyte models. Peptides of China supplies research-grade epithalon as lyophilized powder at ≥98% purity verified by HPLC, confirmed by mass spectrometry. Certificates of Analysis are available per batch. Wholesale quantities are available on request. This product is for laboratory research use only.
Profile
Primary Target hTERT (telomerase), pineal-melatonin axis
Available Variants
| Name | Strength | Pack Size | Purity | Availability |
|---|---|---|---|---|
| Epithalon | 10 mg | 10 vials | ≥98% | In Stock |
| Epithalon | 10 mg | 10 vials | — | In Stock |
| Epithalon | 40 mg | 10 vials | — | In Stock |
| Epithalon | 50 mg | 10 vials | ≥98% | In Stock |
Specification Highlights
Quality & Testing
Testing method: HPLC / LC-MS ([“HPLC”,“LC-MS”,“Endotoxins”,“Water Content”,“Assay”]) . Products are supplied against the specification shown on the applicable product page. The standard catalog purity specification is ≥98% unless otherwise stated. Product-specific specifications and quality-control information may vary by compound and batch. Available documentation: .
**Where provided, these documents reflect the manufacturer’s batch testing for this compound.
Research Areas
Telomerase Activation & Cellular Ageing The most studied mechanism attributed to epithalon is the stimulation of hTERT (human telomerase reverse transcriptase) expression in somatic cells. In primary human fibroblast cultures, epithalon treatment has been reported to increase hTERT mRNA and activity, with associated telomere elongation and extension of the number of population doublings before replicative senescence (Hayflick limit). RPE cell studies published by Khavinson’s group (2003, 2004) documented telomerase activation at nanomolar concentrations. Independent replication and mechanistic elucidation of the signalling pathway (transcriptional vs. post-translational regulation) remain active areas of investigation in this field. Circadian Regulation & Pineal Function Epithalon’s origin as a pineal extract fraction underpins research into its effects on melatonin synthesis and circadian timing. In aged rat models with attenuated pineal melatonin output, epithalon administration has been reported to partially restore nocturnal melatonin peaks and improve circadian rhythm coherence as measured by locomotor activity and thermoregulatory endpoints. In vitro, epithalon stimulates 5-HT acetyltransferase (AANAT) activity in pinealocyte cultures — the rate-limiting step in melatonin synthesis — providing a plausible mechanistic link between the tetrapeptide and melatonin restoration. Antioxidant & Oxidative Stress Models Multiple studies in the Khavinson programme characterise epithalon’s effects on enzymatic antioxidant defence. In lymphocyte, hepatocyte, and erythrocyte models, treatment is associated with increased catalase and superoxide dismutase (SOD) activity, and reduced lipid peroxidation products (TBARS). These observations have been made in both young and aged animal models, with more pronounced effects in the latter — suggesting that the antioxidant response is partially linked to age-associated decline in endogenous antioxidant capacity. The transcriptional mechanism for SOD/catalase upregulation has not been fully characterised. Oncological Research (Anti-tumour Models) A series of rodent tumour model studies from the St. Petersburg group reported that long-term epithalon administration reduced spontaneous tumour incidence in cancer-prone mouse strains (C3H, SHR) and extended mean lifespan. Separate studies in mammary adenocarcinoma-bearing mice reported reduced tumour growth rate and prolonged latency. The proposed mechanisms involve immune regulation, antioxidant protection of DNA, and modulation of transcription factors controlling cell cycle checkpoints. These findings require independent replication in standardised tumour models by external groups. ## Sourcing Epithalon From China
Epithalon is available through our platform as a china peptide sourced directly from an established Chinese manufacturer. Three points define how we handle it:
- Factory-direct, not trader-sourced. We confirm availability and specification with the manufacturer before the order is confirmed. There is no intermediary resale of unknown-origin vials in this catalog.
- Specification before shipment. The purity and concentration specification shown on this page is the manufacturer’s batch specification. Product-specific quality-control information travels with the order.
- Research-use discipline. Like every listing in our catalog, Epithalon is supplied for laboratory research use only, under strict research-use terms.
For buyers comparing chinese peptides suppliers, the practical test is whether the seller can name the manufacturer and show the batch documentation. We work the other way around: the manufacturer and the documentation are the offer. Browse the full catalog or see how sourcing works.