Naturally occurring heptapeptide isolated from Phyllomedusa frog skin. Investigated as a high-affinity μ-opioid receptor ligand in pain pharmacology and opioid receptor binding research.
Dermorphin is a research compound available through our china peptide catalog as a finished, lyophilized vial from an established Chinese manufacturer. It belongs to the D-amino acid containing heptapeptide; μ-opioid receptor agonist Receptor Target μ-opioid receptor (MOR) — high affinity, selective
Research Areas
Opioid receptor pharmacology, MOR binding assays, pain research, β-arrestin signaling, receptor internalization
Available Variants
| Name | Strength | Pack Size | Purity | Availability |
|---|---|---|---|---|
| Dermorphin | 5 mg | 10 vials | ≥98% | In Stock |
Specification Highlights
Quality & Testing
Testing method: HPLC / LC-MS . Products are supplied against the specification shown on the applicable product page. The standard catalog purity specification is ≥98% unless otherwise stated. Product-specific specifications and quality-control information may vary by compound and batch. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control, using methods such as HPLC and LC-MS. These results are kept in the manufacturer’s internal quality-control records and are not issued as a separate certificate or document. Research Areas μ-Opioid Receptor Pharmacology Dermorphin is a reference MOR ligand in opioid receptor research due to its exceptional selectivity and affinity. It is used in radioligand competition binding assays, functional assays (GTPγS binding, cAMP inhibition), and receptor internalization studies as a high-affinity MOR reference. Its D-Ala² modification provides proteolytic resistance not present in endogenous opioids, extending its half-life in tissue homogenates and in vivo — an important practical advantage in pharmacological studies. Pain and Nociception Research As a potent MOR agonist, dermorphin is used in analgesic research in rodent nociception models (tail-flick, hot-plate, formalin, writhing tests). Its high MOR affinity and selectivity make it a useful tool for establishing MOR-specific antinociception baselines and for comparing MOR versus KOR/DOR contributions to pain modulation. It is also used in central versus peripheral opioid distribution studies due to its ability to cross the blood-brain barrier. G Protein versus β-Arrestin Signaling Dermorphin is used in studies examining biased agonism at MOR — the concept that different MOR ligands preferentially activate G protein-coupled signaling (antinociception) versus β-arrestin-mediated signaling (receptor internalization, tolerance). Dermorphin serves as a reference full agonist in these assays, providing a G protein and β-arrestin baseline against which biased compounds are compared. ## Sourcing Dermorphin From China
Dermorphin is available through our platform as a china peptide sourced directly from an established Chinese manufacturer. Three points define how we handle it:
- Factory-direct, not trader-sourced. We confirm availability and specification with the manufacturer before the order is confirmed. There is no intermediary resale of unknown-origin vials in this catalog.
- Specification before shipment. The purity and concentration specification shown on this page is the manufacturer’s batch specification. Product-specific quality-control information travels with the order.
- Research-use discipline. Like every listing in our catalog, Dermorphin is supplied for laboratory research use only, under strict research-use terms.
For buyers comparing chinese peptides suppliers, the practical test is whether the seller can name the manufacturer and show the batch documentation. We work the other way around: the manufacturer and the documentation are the offer. Browse the full catalog or see how sourcing works.
Available Variants
| Name | Strength | Pack Size | Purity | Availability |
|---|---|---|---|---|
| Dermorphin | 5 mg | 10 vials | ≥98% | In Stock |
Specification Highlights
Quality & Testing
Testing method: HPLC / LC-MS . Products are supplied against the specification shown on the applicable product page. The standard catalog purity specification is ≥98% unless otherwise stated. Product-specific specifications and quality-control information may vary by compound and batch. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control, using methods such as HPLC and LC-MS. These results are kept in the manufacturer’s internal quality-control records and are not issued as a separate certificate or document. Research Areas μ-Opioid Receptor Pharmacology Dermorphin is a reference MOR ligand in opioid receptor research due to its exceptional selectivity and affinity. It is used in radioligand competition binding assays, functional assays (GTPγS binding, cAMP inhibition), and receptor internalization studies as a high-affinity MOR reference. Its D-Ala² modification provides proteolytic resistance not present in endogenous opioids, extending its half-life in tissue homogenates and in vivo — an important practical advantage in pharmacological studies. Pain and Nociception Research As a potent MOR agonist, dermorphin is used in analgesic research in rodent nociception models (tail-flick, hot-plate, formalin, writhing tests). Its high MOR affinity and selectivity make it a useful tool for establishing MOR-specific antinociception baselines and for comparing MOR versus KOR/DOR contributions to pain modulation. It is also used in central versus peripheral opioid distribution studies due to its ability to cross the blood-brain barrier. G Protein versus β-Arrestin Signaling Dermorphin is used in studies examining biased agonism at MOR — the concept that different MOR ligands preferentially activate G protein-coupled signaling (antinociception) versus β-arrestin-mediated signaling (receptor internalization, tolerance). Dermorphin serves as a reference full agonist in these assays, providing a G protein and β-arrestin baseline against which biased compounds are compared.
Compound Profile
Dermorphin is a naturally occurring heptapeptide first isolated from the skin of South American tree frogs of the genus Phyllomedusa (particularly P. sauvagii) in 1981. Its sequence — H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH₂ — contains a D-alanine at position 2, which is unusual among endogenous vertebrate peptides and is critical for μ-opioid receptor (MOR) selectivity and metabolic stability. Dermorphin has approximately 30-fold higher affinity for MOR than β-endorphin and is one of the highest-affinity endogenous-like MOR agonists known, making it a valuable pharmacological tool in opioid receptor research. Research applications for dermorphin center on opioid receptor biology. As a selective, high-affinity MOR agonist, it is used as a reference ligand in competition binding assays, receptor internalization studies, and G protein versus β-arrestin signaling research. Dermorphin’s D-amino acid-conferred resistance to enzymatic degradation makes it more stable in biological media than most endogenous opioid peptides, extending its utility in in vivo receptor pharmacology experiments. Its exceptional MOR affinity and selectivity distinguish it from endorphins and enkephalins, which exhibit broader receptor promiscuity. Peptides of China supplies dermorphin as a lyophilized powder at 99%+ purity, verified by HPLC and Mass Spectrometry. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control. All products are for laboratory research use only and are not for human consumption.
Profile
Receptor Target μ-opioid receptor (MOR) — high affinity, selective
Research Areas
Opioid receptor pharmacology, MOR binding assays, pain research, β-arrestin signaling, receptor internalization
Available Variants
| Name | Strength | Pack Size | Purity | Availability |
|---|---|---|---|---|
| Dermorphin | 5 mg | 10 vials | ≥98% | In Stock |
Specification Highlights
Quality & Testing
Testing method: HPLC / LC-MS . Products are supplied against the specification shown on the applicable product page. The standard catalog purity specification is ≥98% unless otherwise stated. Product-specific specifications and quality-control information may vary by compound and batch. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control, using methods such as HPLC and LC-MS. These results are kept in the manufacturer’s internal quality-control records and are not issued as a separate certificate or document. Research Areas μ-Opioid Receptor Pharmacology Dermorphin is a reference MOR ligand in opioid receptor research due to its exceptional selectivity and affinity. It is used in radioligand competition binding assays, functional assays (GTPγS binding, cAMP inhibition), and receptor internalization studies as a high-affinity MOR reference. Its D-Ala² modification provides proteolytic resistance not present in endogenous opioids, extending its half-life in tissue homogenates and in vivo — an important practical advantage in pharmacological studies. Pain and Nociception Research As a potent MOR agonist, dermorphin is used in analgesic research in rodent nociception models (tail-flick, hot-plate, formalin, writhing tests). Its high MOR affinity and selectivity make it a useful tool for establishing MOR-specific antinociception baselines and for comparing MOR versus KOR/DOR contributions to pain modulation. It is also used in central versus peripheral opioid distribution studies due to its ability to cross the blood-brain barrier. G Protein versus β-Arrestin Signaling Dermorphin is used in studies examining biased agonism at MOR — the concept that different MOR ligands preferentially activate G protein-coupled signaling (antinociception) versus β-arrestin-mediated signaling (receptor internalization, tolerance). Dermorphin serves as a reference full agonist in these assays, providing a G protein and β-arrestin baseline against which biased compounds are compared.